Our current results demonstrated that DRAM1 was downregulated in NSCLC patient specimens, and DRAM1 protein was detected in Tp53-wild-type A549 cells, Tp53-null H1299 cells and Tp53-mutant H1975 cells, further indicating that there exists Tp53-independent expression of DRAM1 in NSCLC cells. The gene discussed is DRAM1; the disease is non-small cell lung carcinoma.