EGFR and non-small cell lung carcinoma: In DRAM1-overexpressing NSCLC cells, DRAM1 decreased fluorescent EGF intensity, and the sharper slope of the decrease in fluorescence intensity of 488-EGF, compared with NSCLC cells, also suggested that DRAM1 accelerated the clearance of EGFR in NSCLC cells (Fig. 4a, b).