EGFR and non-small cell lung carcinoma: Treatment with third-generation EGFR-tyrosine kinase inhibitors (TKIs) has markedly improved overall response rate (~79%) and progression-free survival (~64%) in EGFR-mutant NSCLC patients3, while long-term chemotherapy induces mutations of EGFR T790M and C797S, conferring the inevitable acquired resistance and frequent de novo resistance of NSCLC patients to TKIs4.