To test the role of DRAM1 in NSCLC progression, subcutaneous transplantation model using PC9 cells, an EGFR-mutant (exon 19 deletion) NSCLC cell line with a TKI-sensitizing mutation, and DRAM1-overexpressing PC9 cells in nude mice were established. Here, EGFR is linked to non-small cell lung carcinoma.