Assessment of xenografted NSCLC tumors also revealed that overexpression of DRAM1 resulted in lower protein levels of EGFR, p-EGFR, p-ERK, p-AKT, and p-STAT3 than that in PC9 cells with no effect on EGFR mRNA, consistent with the in vitro results mentioned above (Fig. 3c, d and SI 3B). Here, STAT3 is linked to non-small cell lung carcinoma.