How viral infection reduces MAVS level at later time points have been explored by previous reports, from the perspective of miRNA-regulated expression,30 ubiquitination/autophagy-mediated degradation.31,32 Conversely, there are some studies suggesting that MAVS can be deubiquitinated upon virus infection,33 giving us a hint that deubiquitination modification might contribute to the increased MAVS protein level, urgently limiting the replication of virus at the earlier times post infection. The gene discussed is MAVS; the disease is viral infectious disease.