E3 ligase plays an indispensable role in the ubiquitination process.24 In order to define the E3 ligase in Mfn2-mediated MAVS ubiquitination during influenza infection, we initially resorted to UbiBrowser database to make a prediction,25 and SYVN1 was estimated as a potential E3 ligase with the highest score. This evidence concerns the gene SYVN1 and influenza.