EIF2AK3 and pachyonychia congenita: Since we found that both PERK and Nrf2 were upregulated with anlotinib treatment and the ROS production is important in anlotinib-induced apoptosis, we, therefore, considered that the increased expression of Nrf2 in anlotinib-treated PC cells would protect tumours from ROS injury and decreases the tumouricidal effect.