ACE2 and heart failure: The loss of ACE-2 enhances susceptibility to heart failure.54 55 Likewise, a decrease in ACE-2 brings on pneumonia and its activation decreases the inflammatory response in the lungs.56 When ACE-2 is activated, it will prevent binding of SARS-CoV-2 to ACE-2 and check entry into the cell and prevents fibrosis and lung injury by promoting the effect of the enzyme on different organs.