Hence, even in the absence of elevated filling pressures or clinical heart failure, one may come across a rise in NT-proBNP (lower cut-off than in heart failure) in severe COVID-19, which definitely carries a prognostic value on disease outcome besides diagnosing and prognosticating HFpEF/HFrEF in patients with COVID-19 ascribed to a higher cut-off values. This evidence concerns the gene NPPB and heart failure.