The surprising fact is that the cut-off value of NT-proBNP(above 88.64 pg/mL) to predict the adverse outcome of severe COVID-19 has been found to be lower than the threshold, which was used to diagnose heart failure (450 pg/mL for people aged <50 years, 900 pg/mL for people aged 50–75 years and 1800 pg/mL for people aged >75 years). The gene discussed is NPPB; the disease is heart failure.