In addition, METTL3 knockdown inhibited GSC growth and neurosphere formation and reduced the expression levels of stem cell-specific markers, stage-specific embryonic antigen-1 (SSEA1), and glioma reprogramming factors (including POU class 3 homeobox 2 (POU3F2), oligodendrocyte transcription factor 2 (OLIG2), spalt like transcription factor 2 (SALL2) and SOX2). Here, SOX2 is linked to central nervous system cancer.