NOS2 and breast cancer: Meanwhile, the overexpression of linc00514 in breast cancer cells inhibited the THP-1 mRNA levels of TNF-α, NOS2, and IL-6, which are M1 polarization markers of macrophages, while it promoted the expression of Arg-1 at both mRNA and protein levels, which is a M2 polarization marker (Fig. S2A & S2B).