STAT3 and neoplasm: The death rates of mouse in the Si-ctrl group, the Si-STAT3 group, and the Si-JAG1 group were 50% (5/10), 20% (2/10), and 30% (3/10), respectively, and the survival curve was shown in Fig. S3A. After STAT3 knockdown or JAG1 knockdown, the protein expression of Arg-1 in tumor tissues was reduced (Fig. S3B).