GREP1 and breast carcinoma: In human breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF-7), the siRNA-mediated linc00514 knockdown significantly inhibited the viability of breast cancer cells (P < 0.01), while the plasmid-mediated linc00514 overexpression significantly promoted the viability of breast cancer cells (P < 0.01, Fig. 1d).