ESR2 and non-small cell lung carcinoma: Overexpression of CLPTM1L increased ERE-LUC activity in a dose-dependent manner in NSCLC and HEK293T cells, whereas silencing of CLPTM1L decreased ERE-LUC activity in A549 cells (Fig. 5b–c and Additional file 1: Fig. S5B), suggesting that CLPTM1L activated EREs in the promoters of ERβ target genes in NSCLC cells.