The results of the present study suggest a model, in which IR upregulates CLPTM1L and induces the translocation of CLPTM1L into the nucleus, which in turn upregulates the expression of ERβ-induced genes by coactivating ERβ through the LXXLL motif, leading to the radioresistance of NSCLC cells (Fig. 8g). Here, ESR2 is linked to non-small cell lung carcinoma.