ESR2 and non-small cell lung carcinoma: Interestingly, there was a positive correlation between the expression levels of CLPTM1L and ERβ-induced genes in NSCLC tissues without IR (Fig. 3D), and siRNAs for CLPTM1L also had a weak effect on growth of NSCLC cells in the absence of IR, implying another mechanism of oncoprotein CLPTM1L in cytoplasm during the modulation of NSCLC development.