Interestingly, there was a positive correlation between the expression levels of CLPTM1L and ERβ-induced genes in NSCLC tissues without IR (Fig. 3D), and siRNAs for CLPTM1L also had a weak effect on growth of NSCLC cells in the absence of IR, implying another mechanism of oncoprotein CLPTM1L in cytoplasm during the modulation of NSCLC development. This evidence concerns the gene CLPTM1L and non-small cell lung carcinoma.