CLPTM1L and non-small cell lung carcinoma: Moreover, knockdown of CLPTM1L abolished the upregulation of target genes mediated by IR in A549 cells (Additional file 1: Fig. S4B), and IR had no effect on the three target genes in H460 cells (Additional file 1: Fig. S4C), suggesting that IR increased the CLPTM1L-induced upregulation of CDC25A, c-Jun, and BCL2 in radioresistant NSCLC cells.