Adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome (CS) is caused by excessive secretion of ACTH by the pituitary or pituitary tumors, causing bilateral adrenal hyperplasia and excessive cortisol secretion with clinical manifestations such as a moon-shaped face, buffalo hump, and hypertension. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.