CD4 and neoplasm: This may be because SBHFRT resulted in a high rate of tumor cell necrosis in a short term; released a large number of tumor-associated antigens; led to a higher accumulation of DCs to secrete higher levels of IL-12; activated cytotoxic T lymphocytes and CD4+ T cells; produced more IFN-γ, promoting cytotoxic T cell proliferation and activation; and played a role in the positive feedback to adjust the secretion of IL-12 by DCs, while reducing the secretion of IL-10, which is beneficial for the generation of IL-12 and IFN-γ [31, 33, 34].