Enrichment analysis (using Enrichr) of the downregulated genes in females identified significant matches to genes downregulated in the CNS with PD in humans as well as PARK2 and PARK7 knockdown in human neuronal or tumor cell lines, suggesting the Pink1−/− rat model recapitulates genetic and idiopathic PD in humans (Table 1). The gene discussed is PINK1; the disease is Parkinson disease.