In males, downregulated genes of interest that matched human Parkinson disease sequencing datasets included ubiquitin (Gpr37, Trim9), axon guidance (Sema3c), and syntaxin (Stxbp1).Notable upregulated genes that overlapped between the Pink1−/− female rat and human datasets included genes involved in neuron signaling (vesicle (Cd59) sodium channel activity/membrane depolarization (Scn1b), calcium signaling (Ednrb; Mylk), synapse organization (Lrp4)). There were associations with amyloid-beta binding (Clstn1, Cryab, Atp1a3) a neurological feature of protein aggregation in Alzheimer’s disease. Here, SCN1B is linked to early-onset autosomal dominant Alzheimer disease.