NRXN1 and neurodevelopmental disorder: Based on human genetic studies, rare missense variants in NRXN1 have been also linked to broad neurodevelopmental disorders including ASD, SCZ, ID, and seizures [34–36]; however, there are no much studies with functional characterization of SNVs in NRXN1. According to the Exome Aggregation Consortium (ExAC) [37], NRXN1 is defined as a constrained gene with an ExAC missense Z score of 3.02.