This MaAPC displayed the “self-marker” CD47-Fc to prevent macrophage phagocytosis and premature clearance; stimulated effector T cells and established T cell memory with three costimulatory molecules (anti-CD28, anti–4-1BB, and anti-CD2); directed T cell killing against two tumor antigens; and released IL-2, IL-15, and CCL21 together with anti-CTLA-4 and anti-PD-1 ICIs. Here, CD28 is linked to neoplasm.