First, SHBs not only activate IRE1α/XBP1/BECN1 axis-mediated autophagy induction in hepatoma cells, but also activate PERK and ATF6 signaling, in which the downstream molecules eIF2α and GRP78/94 interact with the autophagy-associated proteins ATG5, ATG12, and/or ATG16L to induce UPR-linked autophagy [13,37]. Here, BECN1 is linked to hepatocellular carcinoma.