RNASE2 and type 1 diabetes mellitus: Increases in Eosinophil-derived neurotoxin (EDN) have also been seen in children progressing to clinical T1D [79], which is significant because EDN (also known as ribonuclease A family 2 (RNASE2)) is a ligand for TLR2 and has been shown to enhance dendritic cell (DC) maturation and migration, to promote helper T type 2 (Th2) immune responses and to propagate antiviral responses against ssRNA viruses [80].