ANGPTL1 and neoplasm: Moreover, it has been demonstrated that adipose mesenchymal stem cell-derived EV (ASC-EV), enriched in angiogenic factors such as Milk fat globule-EGF factor 8 (MFG-E8), Angiopoietin Like 1 (ANGPTL1), thrombopoietin and matrix metalloproteinases (MMPs) ease endothelial cell migration and activate a number of signalling pathways, resulting in the growth of the tumour vascular tree [44,45].