The present study verified that resveratrol administration attenuated Con A-exacerbated albuminuria, oxidative stress (increased levels of 8-OH-dG, MDA, and ROS, and a decreased activity of SOD and GSH), and glomerulosclerosis (Masson’s trichrome stain and increased levels in α-SMA, TGF-β, fibronectin, procollagen-III, and collagen I) in the kidney tissues of aged mice, possibly by preventing reductions in klotho and SIRT1 levels. This evidence concerns the gene SIRT1 and glomerulosclerosis.