APOE and familial hyperaldosteronism: Thus, the wGS was calculated for 11 SNPs (wGS11), the six SNPs (wGS6) proposed by Futema et al. [17], and the set of seven SNPs significantly associated with FH in this study as well as APOE rs429358 to include the E2/E3/E4 genotypes (wGS8) (Figure 1).