Emodin, an anthraquinone derivative isolated from many plants including Rheum palmatum, Polygonum cuspidatum, Polygonum multiflorum, and Cassia obtusifolia was also reported to effectively facilitate cisplatin-induced cytotoxicity through multidrug resistance associated protein 1 (MRP1) down-regulation in human bladder cancer T24 and J82 cells [101]. This evidence concerns the gene ABCC1 and urinary bladder cancer.