Even though previous investigations have found numerous molecules such as ATP-binding cassette (ABC) transporter proteins, nucleotide excision repair (NER) gene ERCC1, TP53, Aurora kinases and epithelium-mesenchymal transition (EMT) markers contributed to the resistance of treatment, mainly for chemotherapy, in HNSCC cells [98], successful reports to facilitate treatment sensitivity by targeting these resistance-associated factors are scarce. Here, TP53 is linked to head and neck squamous cell carcinoma.