The cg10759293 probe located within the first intron of NAA20 displayed both the most prominent decreases in its methylation (Figure 3B, right panel) and strongest anti-correlation with gene expression in two tumour types, lung squamous carcinoma (LUSC, r = −0.61) and esophageal carcinoma (ESCA, r = −0.56) (Figure 3C). The gene discussed is NAA20; the disease is carcinoma of esophagus.