Using a multi-omics approach, we have uncovered, in this study, several novel interesting NAT-tumour connections, such as: tumour specific amplifications of NAA40 and NAA15 truncating mutations; recurring mutations of H2A/H4 NAA40 motif; strong anti-correlations between NAA20 first intron methylation and its expression in LUSC and ESCA tumours; ability of NAA11 to compensate for targeting of its homolog NAA10; and an oncogenic role for NAA40 in liver cancer. Here, NAA40 is linked to liver cancer.