It has been recently demonstrated that secondary vasospasm (due to NO inhibition by Hb) and neurotoxicity (due to subarachnoid hemorrhage) were rescued by the infusion of Hp in the cerebral spinal fluid, by a direct inhibition and sequestration of Hb-Hp complexes (m.w. > 100 kD) [104]. Here, HP is linked to subarachnoid hemorrhage.