Similarly, Martinez-Lostao et al. synthesised liposomes conjugated with Apo2 ligand/TNF-related apoptosis-inducing ligand (APO2L/TRAIL), as this group observed that T lymphocytes present in the synovial fluid of rheumatoid arthritis patients are sensitive to activation of both these molecules [111]. Here, TNFSF10 is linked to rheumatoid arthritis.