Especially in the TME, hematopoietic progenitor cells (HPCs) are stimulated by tumor-derived inflammatory factors, e.g., granulocyte-macrophage colony-stimulating factors (GM-CSF), tumor necrosis factor-alpha (TNFα), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2), and differentiate into common myeloid progenitors (CMPs) and granulocyte-macrophage progenitors (GMPs). This evidence concerns the gene CSF2 and neoplasm.