CX3CL1 and Alzheimer disease: It should be mentioned that the central role of Il-18 gene in AD [108], ALS [109, 110], MS [111] and SD [74, 112, 113], and Cx3cl1 gene in all of the six surveyed diseases (i.e. AD [114, 115], ALS [116], HD [117], MS [118], PD [119–122] and SD [123, 124]) has been determined.