AICDA and malignant colon neoplasm: Aicda deficiency was previously reported to decrease inflammation-associated colon cancer in mice, based on the observation that adenocarcinoma had developed in 6 of 22 Il10-/- mice vs. 1 of 23 Il10-/-Aicda-/- mice by ~1 year of age (p = 0.05; [19]).