The generally similar cytokine profiles in TIA and T/I mice, combined with similar histologic severity and extent of inflammation in the colon, strongly suggest that the decreased colorectal neoplasia observed in TIA relative to T/I mice is due to direct or indirect effects of Aicda deficiency that affect mechanisms of carcinogenesis, rather than simply affecting inflammation severity. This evidence concerns the gene AICDA and transient ischemic attack.