The more limited anti-neoplastic effects of Aicda deficiency observed in our study compared with Takai et al [19] may reflect the increased proportion of colon epithelial cells that were exposed to inflammation-associated mutagenesis in our geographically continuous UC-like colitis models compared to the focal CD-like colon inflammation typically characteristic of mice deficient in IL10 alone. The gene discussed is IL10; the disease is colitis.