However, Aicda deficiency was not sufficient to prevent oncogenic mutagenesis in the setting of ongoing inflammation in their model, since although it decreased the percentage of Il10-/- mice that developed invasive colon cancers, it did not affect the percentage of Il10-/- mice with dysplastic precursor lesions such as adenomas at one year of age [19]. Here, AICDA is linked to colonic neoplasm.