These biochemical alterations were more pronounced in infections with liver dysfunction than in those without liver dysfunction: peak AST (468 vs. 1599 U/L; p < 0.001), peak ALT (535 vs. 2857 U/L; p < 0.001), peak Bili (2.13 vs. 8.33 mg/dL; p < 0.001), peak INR (1.32 vs. 1.5; p = 0.083). The gene discussed is FRMD8; the disease is Decreased liver function.