FOXO3 and myeloid sarcoma: Indeed, while this transcription factor is not yet extensively studied in the context of MS, FOXO3 controls Th1 cell differentiation, inhibits oligodendrocyte progenitor cell differentiation, and was shown to exert an important role in neuroinflammation (Stienne et al., 2016; Srivastava et al., 2018; Stefanetti et al., 2018).