According to the recent findings in ARDS, it is concluded that there is a probability of bidirectional alveolar–tubular damage in COVID-19 patients.98 Injured renal tubular epithelium promotes the upregulation of IL-6, which is associated with higher alveolar-capillary permeability and pulmonary hemorrhage.99 The fluid expansion increases alveolar-capillary leakage and AKI. This evidence concerns the gene IL6 and COVID-19.