Angiotensin-converting enzyme 2 is highly expressed by endothelial cells that line the vascular beds of different organs that can be directly infected by SARS-CoV-2.6 Recruitment of immune cells to a site of viral infection can induce endothelial dysfunction associated with apoptosis.6 Therefore, endotheliitis within different organs can be directly caused by a viral infection. This evidence concerns the gene ACE2 and viral infectious disease.