The most likely localization of the viral infection is in interstitial cells or macrophages infiltrating the myocardial tissue rather than localization in the myocytes.14 As heart function is associated with the RAAS, infection by SARS-CoV-2 gives rise to severe damages and dysfunction in the cardiovascular system.9,15 The inflammatory syndrome is mainly initiated by the induction of chemokines and cytokines such as interleukins, interferons (IFNs) and TNF-α. The gene discussed is TNF; the disease is infection.