SNCA and Parkinson disease: The influence of levodopa utilization and pathological changes in cobalamin, folate, and homocysteine levels have been discussed controversially,3, 6, 7 but additional factors are also suspected as several studies have demonstrated dermal nerve involvement in PD including the presence of alpha‐Synuclein (aSyn) pathology in clinically manifest but also in prodromal states.8