Three different variations, NM_000138.4( <i>FBN1</i> ):c.229G > A(p.Gly77Arg), NM_000138.4( <i>FBN1</i> ):c.165-2A > G (novel), NM_000138.4( <i>FBN1</i> ):c.399delC (p.Cys134ValfsTer8) (novel) were determined in our three cases referred with a prediagnosis of Marfan syndrome. This evidence concerns the gene FBN1 and Marfan syndrome.