PON1 and pancreatitis: Therefore, PON1 enzyme activities may alter ROS production or the rate of chemical metabolism, and this may influence the risk of colorectal cancer.24Acute pancreatitis is an inflammatory disease mediated by cytokines, bioactive lipids, and oxidative stress.25Paraoxonase activity is regulated by interleukin-1 and tumor necrosis factor-a26; besides oxidative response,PON1may also be a part of the inflammatory response.