HIF1A and neoplasm: Multivariable analysis adjusted for confounding variables with a univariate P < 0.20 in Supplementary Table 7 (age, clinical stage and site of tumour) identified low HIF1α as an independent prognostic biomarker for improved PFS [HR (95% CI) = 0.62 (0.42–0.93), P = 0.020], LRC [HR (95% CI) = 0.56 (0.37–0.86), P = 0.007] and OS [HR (95% CI) = 0.63 (0.43–0.93), P = 0.019] in the CRT group (Table 2).