pSS is characterized by dry mouth, dry eyes, lymphocytic infiltration of the affected glands (e.g., sialadenitis and dacryoadenitis), and the presence of serum autoantibodies, such as anti-Ro/SSA, anti-La/SSB, rheumatoid factor and anti-nuclear autoantibodies (ANA)2,3. Here, CALR is linked to dry eye syndrome.