HIF2α was present in 0/4 grade II tumors, 72% (8/11) of the grade III gliomas, and 64% (27/42) of the GBMs (Grade IV) with higher percentages of HIF2α staining cells noted in recurrent tumor samples compared to newly diagnosed GBMs (Supplementary Fig. 1). Here, EPAS1 is linked to glioma.