In gliomas, HIF2α is expressed in glioma cells but not in normal neural progenitors or glia15,16 and may be clinically relevant as HIF2α expression in the REMBRANDT glioma database (n = 834) showed higher HIF2α expression in tumors correlates with increased grade of malignancy and poorer patient survival15. Here, EPAS1 is linked to central nervous system cancer.