EPAS1 and renal cell carcinoma: To document a direct link between HIF2α expression and hypoxia, two low-passage, adult patient-derived GBM cell lines (BTCOE 4536 and BTCOE 4795, Supplementary Table 1) were cultured in both normoxic and hypoxic conditions for 72 h and compared to a renal cell carcinoma cell line (Caki1) known to upregulate HIF2α in hypoxia.