SAV1 and heart disorder: Using gain- and loss-of-function genetic models, it was shown that the Hippo-YAP signaling pathway components Mst1/2, Sav1, Lats1/2, NF2, and downstream transcriptional regulators YAP and Tead1 regulate cardiac gene expression, cardiomyocyte proliferation, and cardiac disease status14,27,28.