However, reducing the levels of either ImpL2 (ras1G12V;csk−/−,ImpL2RNAi) or Pvf1 (ras1G12V,pvf1RNAi;csk−/−) failed to rescue muscle wasting as efficiently as bnl in our HSD-enhanced Ras/Src-tumour model (Supplementary Fig. 3h–k, q). The gene discussed is SRC; the disease is neoplasm.