Reducing bnl expression in Ras/Src-activated tumours (ras1G12V;csk−/−,bnlRNAi) attenuated muscle wasting in animals raised on an HSD (Fig. 2g, h, k and Supplementary Fig. 3f, g, q), indicating that tumour-derived Bnl is required for muscle wasting. Here, SRC is linked to neoplasm.