Reducing the expression of mnd (ras1G12V;csk−/−,mndRNAi), JhI-21 (ras1G12V;csk−/−,JhI-21RNAi), slif (ras1G12V;csk−/−,slifRNAi) or CG8785 (ras1G12V;csk−/−, CG8785RNAi) had no effect on primary tumour size (Fig. 4b–f and Supplementary Fig. 5g). The gene discussed is CSK; the disease is neoplasm.