CHST3 and neoplasm: Furthermore, reducing bnl expression in HSD-enhanced Ras/Src-tumours (ras1G12V;csk−/−,bnlRNAi) not only attenuated systemic muscle wasting (Fig. 2g, h and Supplementary Fig. 3f, g, p), but also reduced circulating levels of proline (Supplementary Fig. 4d).