In agreement with this, in cancer entities where ATF4 activity (assayed as ASNS mRNA levels) correlates with survival (e.g. renal cancer and liver hepatocellular carcinoma) (Supplementary Fig. 8a), also DENR or MCTS1 levels have prognostic value (Supplementary Fig. 8a). This evidence concerns the gene MCTS1 and renal carcinoma.