Bioinformatics analysis predicted 36 transcriptional factors that could bind to PGC1α promoter region, 8 of which [IRF1, zinc finger protein 354C (ZNF354C), Meishomeobox 1 (MEIS1), transcription factor 12 (Tcf12), forkhead box L1 (FOXL1), poly(A) binding protein cytoplasmic 1 (PABPC1), breast cancer type 1 susceptibility protein (BRCA1), and insulin-like growth factor 1 receptor (IGF1R)] were associated with cardiac hypertrophy. The gene discussed is BRCA1; the disease is cardiac hypertrophy.