Consistent with cardiac hypertrophy observed in Rreb1+/− mice and sensitization of MAPK signaling in RREB1 haploinsufficient cells, increased p-MEK and p-ERK was observed in left ventricle (LV) from Rreb1+/− hearts compared to WT (Fig. 2i). The gene discussed is MAP2K7; the disease is cardiac hypertrophy.