HDAC1 and central nervous system cancer: Furthermore, querying two publicly available databases, The Cancer Genome Atlas (TCGA) and The Repository for Molecular Brain Neoplasia Database (Rembrandt), revealed that HDAC1 expression was positively correlated with a higher grade of glioma (TCGA: n = 213 (Supplementary Fig. 5e); Rembrandt: n = 446 (Fig. 5f)).