Disruption of circadian rhythm has been shown to lead to metabolic dysregulation (Froy, 2011; Barclay et al., 2012), including Type-2 diabetes (T2D) (Marcheva et al., 2010; Shan et al., 2018; Pan et al., 2011) and insulin-sensitivity (Coomans et al., 2013). This evidence concerns the gene INS and type 2 diabetes mellitus.