GPT and leukemia: This damage-induced mobility of the telomere was proposed to mediate inter-chromosomal homology search preceding recombination between non-sister telomeres, analogous to the pairing of homologues in meiosis I. Indeed, telomere clustering in ALT-associated promyelocytic leukaemia bodies (APBs) is a hallmark of ALT, and APB formation has been linked to ALT activity [117,118].