Formation of the HR mediator complex, comprised of the breast cancer 1 (BRCA1), the breast cancer 2 (BRCA2) and the partner and localiser of BRCA2 (PALB2) proteins, plays a major role in promoting RAD51 recruitment to the break site, where BRCA2 facilitates assembly of the RAD51 nucleoprotein filament at the resected DNA end [[6], [7], [8]]. Here, BRCA1 is linked to cancer.