IGF1 and metabolic syndrome: IR seems to be essential in the pathophysiological process, and for this reason, based on the information available, we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome due to its implications in the metabolism of carbohydrates and lipids [68].IGF-1 is a homologue molecule that acts predominantly as an anabolic hormone involved in cell growth, differentiation, and migration [69].