In the previously characterized C. elegans ALS model, wild-type human SOD1 (SOD1-WT) or mutant human SOD1 carrying the patient amino acid change G85R (SOD1-G85R) are expressed at high levels using a pan-neuronal C. elegans promoter (from the snb-1 gene). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.