By analyzing the PPI network, the 10 hub DEGs ITGAL, TLN1, POLR2A, CD69, GZMA, VASP, HNRNPUL1, SF1, SRRM2 and ITGAV were selected, among which ITGAL, TLN1, POLR2A, VASP, HNRNPUL1, SF1 and SRRM2 were expressed at higher levels while the expression levels of CD69, GZMA and ITGAV were lower in FH patients. The gene discussed is POLR2A; the disease is familial hyperaldosteronism.