Specifically, up-regulated ITGAL, TLN1, POLR2A, VASP, HNRNPUL1, SF1, SRRM2, and down-regulated, CD69, GZMA,ITGAV performed important promotional effects for the formation of atherosclerotic plaques those with FH. The gene discussed is SRRM2; the disease is familial hyperaldosteronism.