In order to better illustrate the use of miRTissue ce in the analysis of biomarker discovery in cancer, we report a specific example: First of all, filtering for Breast Cancer (BRCA) tissue and for PTEN tumor suppressor gene, ceRNA network analysis evidenced an interaction between PTEN, many miRNAs, and ceRNA interactors (mRNAs, lncRNAs and pseudogenes). The gene discussed is PTEN; the disease is cancer.