Contrary to this induction of Nrf2 activity, another investigation with apigenin reported increased miR-101 levels targeting the 3′UTR of NFE2L2 mRNA, with enhanced chemosensitivity of doxorubicin-resistant human hepatocellular carcinoma BEL-7402/ADM cells [106]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.