SOD2 and metabolic dysfunction-associated steatohepatitis: As identified by the key driver analysis in the NASH livers, the upregulation of proteins involved in protection from oxidative stress like Mgst1 and Gstp1 [87] may be interpreted as an adaptive response to increased oxidative stress, while downregulation of proteins like Sod2 involved in mitochondrial superoxide detoxification may even aggravate oxidative stress and mitochondrial impairment [88].