Similar to BiTes, bi-, tri-, and tetra-specific killer engagers (BiKEs, TriKEs, TetraKEs) have been engineered to form an antigen-specific immunological synapse between tumour cells and NK cells via an anti-CD16 component instead of CD3 with the aim to effect NK cell-mediated killing of their tumour targets [397]. The gene discussed is FCGR3A; the disease is neoplasm.