TILs include CD8+ T-cells, Tregs, regulatory B-cells (Bregs), type II NK T-cells (which recognise lipid antigens and are not the same as NK cells), and Th2 CD4+ cells which upregulate B-cell responses, play roles in remodeling and may or may not promote tumour growth [68,71]. This evidence concerns the gene CD8A and neoplasm.