HLA-C and neoplasm: Advantages of NK cells include: (1) the lack of GVHD due to their reaction to lowly expressed or absent MHC rather than mis-matched MHC; (2) their relatively limited life-span, permitting effective antitumor activity while reducing the probability of long-term adverse events, due to on-target/off-tumor toxicity to normal tissues); (3) CAR-NK cells retain their intrinsic capacity to recognise and target tumor cells through their native receptors [400].