However, loss of IFNγ expression in Tregs deficient for the Th1 lineage commitment transcription factor Tbet, showed a defective Th1 immune response in a mouse model of colitis thus suggesting that FoxP3+Tbet+ T cells expressing IFNγ might be instrumental for the generation of a Th1 immune response in the sporadic CRC context [94]. Here, TBX21 is linked to colorectal carcinoma.