ESR1 and breast cancer: Moreover, Rovito and coworkers have demonstrated that long-term treatment with the conjugates of EPA and DHA with dopamine (DA), EPADA, and DHADA, respectively, induced apoptosis in different human breast cancer cell lines, including MCF-7 (ERα positive), SKBR3 (ER/PR double negative and HER2 overexpressing), and MDA-MB-231 (triple negative) cells after the blockade of the autophagic flux.